人类四肢是如何进化的？

Sharks, skates, and rays are oddities among the fish: They have appendages ¹ growing out of the gill arch, a small cradle of bones that supports the gills. This anatomical peculiarity ² has led to the proposal that the paired limbs of humans, and before that the paired fins ³ of fish, evolved from the transformation ⁴ of gill arches in early fish. Genetic ⁶ evidence for this theory is offered in a new study led by J. Andrew Gillis, a Royal Society University Research Fellow at the University of Cambridge, U.K., and a Whitman Center scientist at the Marine ⁷ Biological Laboratory (MBL) in Woods Hole, Mass. , ,The study, published this week in Development, demonstrates striking similarities in the genetic mechanism ⁸ used to pattern gill arch appendages (called branchial rays) and fins/limbs., ,Studying embryos ⁹ of the little skate, Gillis focused on the gene ⁵ Sonic hedgehog, which produces a signaling protein whose function is well understood in the mammalian limb. Remarkably ¹⁰, he found that Sonic hedgehog's role in branchial rays closely parallels its role in the limb: it sets up the axis ¹¹ of development and, later, maintains growth of the limb skeleton., ,"The shared role of Sonic hedgehog in patterning branchial rays and limbs may be due to a deep evolutionary ¹² relationship between the two," Gillis says, "or it may simply be that two unrelated appendages independently use the same gene for the same function." Ongoing ¹³ studies comparing the function of other genes ¹⁴ during branchial ray and fin/limb development will help to resolve this. Gillis will continue his research at the MBL this summer using skates collected and supplied by the Marine Resources Department., ,"Branchial rays will figure prominently in the story of the evolutionary origin of vertebrate animal appendages, either by shedding light on the evolutionary antecedent of paired fins/limbs, or by teaching us about the genetic mechanisms ¹⁵ that animals can use to invent new appendages," Gillis says.