水螅可以修改自己的基因程序

Champion of regeneration, the freshwater polyp Hydra ² is capable of reforming a complete individual from any fragment of its body. It is even able to remain alive when all its neurons have disappeared. Researcher the University of Geneva (UNIGE), Switzerland, have discovered how: cells of the epithelial type modify their genetic ³ program by overexpressing a series of genes ⁴, among which some are involved in diverse nervous functions. Studying Hydra cellular ⁵ plasticity may thus influence research in the context of neurodegenerative diseases. The results are published in Philosophical ⁶ Transactions of the Royal Society. The freshwater Hydra is endowed with an extraordinary power of regeneration, discovered by the Swiss naturalist ⁷ Abraham Trembley more than 250 years ago. The group of Brigitte Galliot, professor at the Department of Genetics and Evolution of the Faculty ⁸ of Science of UNIGE, has studied the stem cells functioning and cellular plasticity of the polyp: &laquoits nervous system regulates in particular contraction ⁹ bursts, feeding behavior, moving or swimming. If the stem cells responsible for its renewal ¹⁰ are depleted ¹¹, the Hydra can still develop, even when all its neurons have disappeared. We wanted to understand how this is possible., ,Enhancing other cells' sensing ability, ,The researchers compared gene ¹ expression at various positions along the body axis ¹² in polyps devoid ¹³ or not of their nervous stem cells. They observed a modification ¹⁴ of the genetic program in animals depleted of these cells: &laquowe identified 25 overexpressed genes in epithelial cells, the cells forming the Hydra's coating tissues. Some of these genes are involved in diverse nervous functions, such as neurogenesis or neurotransmission», says Yvan Wenger, co-first author of the article. , ,&laquoEpithelial cells do not possess typical neuronal functions. However, Hydra's loss of neurogenesis induces epithelial cells to modify their genetic program accordingly, indicating that they are ready to assume some of these functions. These "naturally" genetically ¹⁵ modified epithelial cells are thus likely to enhance their sensitivity and response to environmental signals, to partially ¹⁶ compensate ¹⁷ for the lack of nervous system», explains Wanda Buzgariu, co-first author of the article. The detail of these new functions remains ¹⁸ to be discovered, as well as how epithelial cells proceed to overexpress these genes and thus adapt their genetic program.