长期暴露于污染空气中会损坏大脑结构

Air pollution, even at moderate levels, has long been recognized as a factor in raising the risk of stroke. A new study led by scientists from Beth Israel Deaconess Medical Center and Boston University School of Medicine suggests that long-term exposure can cause damage to brain structures and impair ¹ cognitive ² function in middle-aged ³ and older adults. Writing in the May 2015 issue of Stroke, researchers who studied more than 900 participants of the Framingham Heart Study found evidence of smaller brain structure and of covert ⁴ brain infarcts, a type of "silent" ischemic stroke resulting from a blockage ⁶ in the blood vessels ⁷ supplying the brain., ,The study evaluated how far participants lived from major roadways and used satellite imagery to assess prolonged exposure to ambient fine particulate ⁸ matter, particles with a diameter of 2.5 millionth of a meter, referred to as PM2.5. These particles come from a variety of sources, including power plants, factories, trucks and automobiles ⁹ and the burning of wood. They can travel deeply into the lungs and have been associated in other studies with increased numbers of hospital admissions for cardiovascular events such as heart attacks and strokes., ,"This is one of the first studies to look at the relationship between ambient air pollution and brain structure," says Elissa Wilker, ScD, a researcher in the Cardiovascular Epidemiology Research Unit at Beth Israel Deaconess Medical Center. "Our findings suggest that air pollution is associated with insidious ¹⁰ effects on structural ¹¹ brain aging, even in dementia- and stroke-free individuals.", ,Study participants were at least 60 years old and were free of dementia and stroke. The evaluation ¹² included total cerebral ¹³ brain volume, a marker of age-associated brain atrophy ¹⁴; hippocampal volume, which reflect changes in the area of the brain that controls memory; white matter hyperintensity volume, which can be used as a measure of pathology and aging; and covert brain infarcts., ,The study found that an increase of only 2µg per cubic meter in PM2.5, a range commonly observed across metropolitan ¹⁵ regions in New England and New York, was associated with being more likely to have covert brain infarcts and smaller cerebral brain volume, equivalent to approximately one year of brain aging., ,"These results are an important step in helping ¹⁶ us learn what is going on in the brain," Wilker says. "The mechanisms ¹⁷ through which air pollution may affect brain aging remain unclear, but systemic inflammation resulting from the deposit of fine particles in the lungs is likely important.", ,"This study shows that for a 2 microgram per cubic meter of air (μg/m3) increase in PM2.5, a range commonly observed across major US cities, on average participants who lived in more polluted areas had the brain volume of someone a year older than participants who lived in less polluted areas. They also had a 46 percent higher risk of silent strokes on MRI," said Sudha Seshadri, MD, a Professor of Neurology at Boston University School of Medicine and Senior Investigator ¹⁸, the Framingham Study., ,"This is concerning since we know that silent strokes increase the risk of overt ⁵ strokes and of developing dementia, walking problems and depression. We now plan to look at more the impact of air pollution over a longer period, its effect on more sensitive MRI measures, on brain shrinkage over time, and other risks including of stroke and dementia."