丙肝病毒迄今最详细的图像

Scientists at The Scripps Research Institute (TSRI) have determined ¹ the most detailed ² picture yet of a crucial part of the hepatitis（肝炎） C virus, which the virus uses to infect liver cells. The new data reveal unexpected structural ³ features of this protein and should greatly speed efforts to make an effective hepatitis C vaccine ⁴. The findings, which appear in the November 29, 2013 issue of the journal Science, focus on a protein known as E2 envelope glycoprotein（包膜糖蛋白）., ,"We're excited by this development," said Ian A. Wilson, the Hansen Professor of Structural Biology at TSRI and a senior author of the new research with TSRI Assistant Professors Mansun Law and Andrew B. Ward ⁵. "It has been very hard to get a high resolution structure of E2 and it took years of painstaking ⁶ work to finally accomplish that.", ,Any successful hepatitis C vaccine is likely to target the E2 protein. Scientists already have isolated ⁷ rare antibodies from patients that can bind ⁸ E2 in ways that neutralize ⁹ a broad range of viral strains., ,"It took our team six years to crack this very difficult scientific problem, but we didn't give up," said Law. "Now that we can visualize ¹⁰ the structural details of these binding ¹¹ sites, we can design vaccine molecules ¹² that mimic ¹³ them."