濒死的大脑如何产生意识

The "near-death experience" reported by cardiac arrest survivors ¹ worldwide may be grounded in science, according to research at the University of Michigan Health System. Whether and how the dying brain is capable of generating conscious activity（意识活动） has been vigorously debated., ,But in this week's PNAS Early Edition, a U-M study shows shortly after clinical death, in which the heart stops beating and blood stops flowing to the brain, rats display brain activity patterns characteristic of conscious perception., ,"This study, performed in animals, is the first dealing ² with what happens to the neurophysiological state of the dying brain," says lead study author Jimo Borjigin, Ph.D., associate professor of molecular ³ and integrative（综合的） physiology ⁴ and associate professor of neurology at the University of Michigan Medical School., ,"It will form the foundation for future human studies investigating mental experiences occurring in the dying brain, including seeing light during cardiac arrest," she says., ,Approximately 20 percent of cardiac arrest survivors report having had a near-death experience during clinical death. These visions and perceptions have been called "realer than real," according to previous research, but it remains ⁵ unclear whether the brain is capable of such activity after cardiac arrest., ,"We reasoned that if near-death experience stems from brain activity, neural ⁶ correlates of consciousness should be identifiable in humans or animals even after the cessation（停止） of cerebral ⁷ blood flow," she says., ,Researchers analyzed ⁸ the recordings ⁹ of brain activity called electroencephalograms (EEGs) from nine anesthetized rats undergoing experimentally induced cardiac arrest., ,Within the first 30 seconds after cardiac arrest, all of the rats displayed a widespread, transient surge of highly synchronized ¹⁰ brain activity that had features associated with a highly aroused brain., ,Furthermore, the authors observed nearly identical patterns in the dying brains of rats undergoing asphyxiation ¹¹., ,"The prediction that we would find some signs of conscious activity in the brain during cardiac arrest was confirmed with the data," says Borjigin, who conceived the idea for the project in 2007 with study co-author neurologist Michael M. Wang, M.D., Ph.D., associate professor of neurology and associate professor of molecular and integrative physiology at the U-M., ,"But, we were surprised by the high levels of activity," adds study senior author anesthesiologist George Mashour, M.D., Ph.D., assistant professor of anesthesiology and neurosurgery at the U-M. " In fact, at near-death, many known electrical signatures of consciousness exceeded levels found in the waking state, suggesting that the brain is capable of well-organized electrical activity during the early stage of clinical death."