骨密度与质量共同影响骨折的风险性
- 指点迷津
- 2024-11-30
- 11
In a study carried out at the University of Eastern Finland, bone
histomorphometry(组织形态测定术) and
infrared
1 spectroscopy revealed abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. Bone compositional changes in children with vertebral fractures and after different types of organ transplantation have not been reported
previously
2. Bone samples were investigated using bone histomorphometry, a
microscopic
3 method that provides information about bone
metabolism
4 and
remodelling
5. In children with vertebral fractures, there were changes in bone composition, such as lower carbonate-to-phosphate-ratio and increased collagen
maturity
6, which could explain the increased fracture risk. The results also suggest that in children who have undergone kidney, liver or heart transplantation, the various changes related to bone microarchitecture and
turnover
7 may be more important predictors of fracture risk than lowered bone mineral
density
8 alone. Early detection of such changes in bone quality could help prevent fractures., ,Osteoporosis(骨质疏松症) is the most common
metabolic
9 bone disease characterized by abnormal bone formation and resorption which lead to increased risk of bone fractures. However, the present diagnostics based on the measurement of bone mineral density predict fractures only moderately. In addition to decreased bone mineral density, changes in bone quality could explain increased fragility related to osteoporosis. The present study confirmed that bone histomorphometry is needed in clinical practice to study remodelling balance in bone in certain patient groups., ,"Especially in clinically challenging
scenarios
10 where different treatment options are being considered, bone histomorphometry provides valuable information. An accurate
diagnosis
11 and choice of medication are especially important when treating paediatric patients," says Ms Inari Tamminen, MD, whose doctoral thesis on the topic was published in June., ,The findings were originally published in Journal of Bone and Mineral Research and Journal of Bone and Mineral Metabolism., ,The histomorphometry laboratory at the University of Eastern Finland in Kuopio is one of the few in the world
analyzing
12 clinical bone biopsies. More than 70 patient samples are
analyzed
13
annually
14. Over 30 years of
expertise
15 in
quantitative
16 histomorphometry have formed a solid basis for high quality research. Recent projects focus on paediatric patients with osteoporosis,
genetic
17
disorders
18 and insufficiency fractures.
本文由明日于2024-11-30发表在生活百科-红苹果乐园,如有疑问,请联系我们。
文章摘自:http://hpgly.com/post/34981.html
上一篇
气候变化对土壤的影响
下一篇
热带树木不宜长期收采
发表评论